Fig. 6. Limited HIF-1 transcriptional response in episodic hypoxia. Real time PCR analysis of HIF-1 target genes (A) aldolase C (Aldoc), (B) hexokinase 2 (HK2), (C) solute carrier family 2 (Slc2a1, alias Glut1), and (D) adrenomedullin (Adm) in DCT cells. Values were normalized to 18S ribosomal RNA and significant differences to normoxia indicated with hash signs ###: p<0.001, ##: p<0.01. Asterisks denote significance between hypoxic groups. **: p<0.01, and ***: p<0.001. Error bars indicate standard deviation (n=6).